Job details
Job type full-time
Full job description
Cambridge, ma-based h3 biomedicine (h3b) is a leading company in cancer genomics driven drug discovery, delivering on the promise of precision medicineThe company was launched in 2011 with an unprecedented $200 million in initial funding from eisai, plus a continued ongoing commitment to fund h3b’s robust discovery pipeline and clinical programsNow with three clinical stage anti-cancer molecules in active development, h3b is able to uniquely leverage distinct insights from cancer genomics and real-life patient data to advance its projects to clinical proof of concept and beyondH3b embraces a novel business model in which it collaborates with eisai, a leading global pharmaceutical company, to create a prolific drug discovery engine and partnership platform.
We have an exciting opportunity to join a fantastic team of scientists as a postdoc in structural biologyH3 biomedicine is at the forefront of cancer genomics and drug discoveryStructural biology plays a prominent role in underpinning our mechanistic understanding of disease biology and empowering our drug design.
Principal duties and responsibilities
Function as an outstanding protein chemist with a phd in structural biology with an emphasis in cryo-em or x-ray crystallography.
Assist with a range of projects in our oncology portfolio from early to late stage with numerous opportunities for publication.
These projects include elucidating the structures of large proteins (>150 kd) and protein complexes that will provide new insights into cancer biology.
To enable these projects, h3 has invested in a gpu workstation for in house data processing / reconstruction and has entered into relationships with both u mass and nanoimaging for data collection.
The successful candidate will also be encouraged to collaborate and consult with academic advisors as needed.
We desire an individual with attention to detail, motivation, independence, and ambition to further our mission to improve patient lives.
Qualifications
Construct design
Expression systems (e coli, insect cells, and mammalian)
Experienced akta user
Western blots
Cross-linking techniques
Sample prep for negative stain and cryo-em techniques
Data processing (particle picking, 2-d classification, 3-d reconstruction, model building, refinement)
Software ccp4, ccp-em, relion, cistem, coot, pymol
Excellent written and verbal communication
Nice to have: crystallization techniques (basics screening, optimization, seeding, soaking, harvesting, freezing)
Eisai requires all new hires to be fully vaccinated against covid-19 and provide valid proof of vaccination as of their start date, to the extent permitted under state lawThis requirement is a condition of employment at eisai, and it applies regardless of whether the position is located at an eisai site, field based or is fully remoteIf you are unable to receive the vaccine due to a medical condition (including pregnancy-related), or because of your sincerely held religious beliefs, you will have an opportunity to request a reasonable accommodation
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H3 biomedicine is an equal opportunity employer and as such, is committed in policy and in practice to recruit, hire, train, and promote in all job qualifications without regard to race, color, religion, gender, age, national origin, citizenship status, marital status, sexual orientation, gender identity, disability or veteran statusSimilarly, considering the need for reasonable accommodations, h3 biomedicine prohibits discrimination against persons because of disability, including disabled veterans.
H3 biomedicine incParticipates in e-verifyE-verify is an internet based system operated by the department of homeland security in partnership with the social security administration that allows participating employers to electronically verify the employment eligibility of all new hires in the united states.
