Position:
Principal/sr principal scientist, dmpk (multiple locations)
Function:
Discovery small molecule
Location:
Boulder, co
Position summary:
Loxo oncology at lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patientsLoxo oncology at lilly was created in december 2019, combining the lilly research laboratories oncology organization and loxo oncology, which was acquired by lilly in early 2019The unit has team members in boulder, co, indianapolis, in, new york city, ny, south san francisco, ca, san diego, ca, stamford, ct, and madrid, spain.
Loxo oncology at lilly’s drug discovery team has an immediate opening for an experienced drug metabolism scientistThe loxo oncology at lilly team’s mission is to invent life-changing targeted therapies for cancer patient populations that are poorly treated by existing therapiesTo that end, we have built a multi-disciplinary team of dedicated drug discovery scientists who are passionate about driving the science forward to create highly selective drugs for known oncogenic driversWe are currently looking for accomplished dmpk program representative with a proven track records of success in small molecule drug discoveryThe ideal candidate will be passionate about solving complex dmpk challenges and will excel at working closely with scientists across disciplinesThe position requires excellent people skills, a positive can-do attitude, and the ability to thrive in a highly interactive, fast-paced, team environment.
Roles and responsibilities for this postion
Design and execute in vitro and in vivo preclinical studies to understand the pharmacokinetics (pk) and absorption, metabolism, distribution, and excretion (adme) of new chemical entities (nce)
Provide management and oversight of cros in the conduct of in vitro and in vivo adme studies
Advise medicinal chemistry teams on complex dmpk issues
Perform non-compartmental pharmacokinetic analysis on data
Review in vivo protocols and study reports
Collate data and present to program teams
Contribute to authoring and review of regulatory reports and documents
Maintain accurate and timely electronic lab notebook
Bs, ms or ph.dIn medicinal chemistry, biochemistry or related discipline
Bs with 10+, ms with 8+ or ph.dWith 5+ years of dmpk experience
Experience managing and overseeing cros
Experience managing bioanalytical and pharmacokinetic studies strongly preferred
Must have pharmacokinetic modeling experience
Experience with bioanalysis method and assay development
Good written and oral presentation capabilities
Available locations for this role
Boulder/louisville, colorado
Remote (us based)
Physical demands/ travel: the physical demands of this job are consistent with light office dutiesThe physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this jobWork environment: this position’s work environment is in an officeThe work environment characteristics described here are representative of those an employee encounters while performing the essential functions of this job.
Loxo oncology, inc(loxo) currently anticipates that the base salary for this position could range from between $103,200 to $151,423 for a principal scientist and $118,700 to $174,137 for a srPrincipal scientist and will depend, in part, on the successful candidate’s qualifications for the role, including education and experienceThis position also will be eligible for a company bonus(depending, in part, on company and individual performance)In addition, loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain itemsThe compensation described above is subject to change and could be higher or lower than the range described aboveFurther, loxo reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion.
To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorilyThe requirements listed above are representative of the knowledge, skill, and/or ability requiredReasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.
Loxo oncology, incIs an eeo/affirmative action employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected statusAs a condition of employment with loxo, a wholly owned subsidiary of eli lilly and company, in the united states and puerto rico, you must be fully covid-19 vaccinated and provide proof of vaccination satisfactory to the companyIf you would like to request an accommodation for medical or religious reasons, you may do so at workplace_adjustment@lilly.com
